Diastolic Dysfunction and Interstitial Lung Edema in Septic Patients

Study Purpose

Sepsis is one of the most challenging conditions with an exceptionally high mortality rate. Diastolic Dysfunction is common in septic patients and has been found to be associated with mortality. However, the reasons for this remain unclear. Therefore, the goal of this study is to investigate diastolic dysfunction in septic patients on the intensive care unit. Special attention is paid to the presence of lung edema and general edema as a potential link between diastolic dysfunction and elevated mortality in septic patients. During the septic phase daily ultrasound examinations of heart and lung will be performed as to monitor diastolic function and lung edema.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.

An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.

Searching Both is inclusive of interventional and observational studies.

Eligible Ages 30 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Patients on the intensive care unit diagnosed with SIRS (systemic inflammatory response syndrome) or Sepsis.

Exclusion Criteria:

  • - Patients with hemodynamically relevant cardiac defects.
  • - Patients with mitral valve replacement.
  • - Patients with pericardial effusion.
  • - Patients with atrial fibrillation.
  • - Patients with pacemaker therapy.
  • - Patients with BMI > 35 kg/m2.
  • - Patients with poor examination conditions for ultrasound.

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.


Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Universitätsklinikum Hamburg-Eppendorf
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Ursula Kahl, MD
Principal Investigator Affiliation Klinik und Poliklinik für Anästhesie Universitätsklinikum Hamburg-Eppendorf
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Overall Status Recruiting
Countries Germany

The disease, disorder, syndrome, illness, or injury that is being studied.

Sepsis, Diastolic Dysfunction, Lung Edema, Fluid Overload
Arms & Interventions


: Diastolic Dysfunction

Patients with pre-existing or new diastolic dysfunction.

: Normal Diastolic Function

Patients with normal diastolic function.


Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

International Sites

Hamburg, Germany




Universitätskrankenhaus Hamburg-Eppendorf

Hamburg, , 20246

Site Contact

Silke Schrum, Dr.


+49 (0) 40 7410 - 54290

Terms of Service

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