Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.
An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.
Searching Both is inclusive of interventional and observational studies.
|Eligible Ages||18 Years and Over|
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.
Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.
Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.
Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.
|University College, London|
The person who is responsible for the scientific and technical direction of the entire clinical study.
|Doris-Eva Bamiou, ProfessorDavid Werring, Professor|
|Principal Investigator Affiliation||The Ear Institute, University College London; Department of Neuro-otology, University College London Hospitals, London, UKDepartment of Brain Repair and Rehabilitation, Stroke Research Centre, Institute of Neurology, University College London; Department of Neurology, University College London Hospitals, London, UK|
Category of organization(s) involved as sponsor (and collaborator) supporting the trial.
|Overall Status||Not yet recruiting|
The disease, disorder, syndrome, illness, or injury that is being studied.
|Siderosis, Neurological Disorder, Rare Diseases, Age Related Hearing Loss, Presbycusis|
|Study Website:||View Trial Website|
: Siderosis (iSS) group
participants with a known diagnosis of infratentorial superficial siderosis (defined using standardised radiological criteria) confirmed by a consultant neurologist with expertise in this condition at University College London Hospitals National Health Service (NHS) Foundation Trust
: Age-related hearing loss (ARHL) group
participants with age-related hearing loss (as identified from participant's clinical history and examination, with hearing thresholds confirmed on a pure-tone audiogram)
: Control group
participants with no known or previously reported hearing loss (as identified from participant's clinical history and examination, with hearing thresholds confirmed on a pure-tone audiogram)
Diagnostic Test: - Hearing assessment
All study participants will undergo hearing tests, including dedicated questionnaires
Diagnostic Test: - Vestibular/balance assessment
Siderosis group participants will undergo vestibular/balance tests, including gait assessment and dedicated questionnaires
Other: - Quality of life assessment
All study participants will be asked to complete a set of quality of life questionnaires
Diagnostic Test: - Olfactory (smell) function testing
Siderosis group participants will undergo a formal smell identification testing by means of self-administered smell chart to identify the revealed scents
Genetic: - DNA bio-banking
Siderosis group participants will undergo peripheral venous blood sampling for DNA bio-banking
This trial has no sites locations listed at this time. If you are interested in learning more, you can contact the trial's primary contact:
Natallia Kharytaniuk, Dr
For additional contact information, you can also visit the trial on clinicaltrials.gov.