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Zephyrus II: Efficacy and Safety Study of Pamrevlumab in Participants With Idiopathic Pulmonary Fibrosis (IPF)

Study Purpose

This is a Phase 3 trial to evaluate the efficacy and safety of 30 milligrams (mg)/kilogram (kg) intravenous (IV) infusions of pamrevlumab administered every 3 weeks as compared to placebo in participants with Idiopathic Pulmonary Fibrosis (IPF). There is a 48-week randomized treatment phase followed by an optional, open-label extension phase.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 40 Years - 85 Years
Gender All
More Inclusion & Exclusion Criteria

Key

Inclusion Criteria:

1. Diagnosis of IPF as defined by American Thoracic Society/European Respiratory Society/Japanese Respiratory Society/Latin American Thoracic Association (ATS/ERS/JRS/ALAT) guidelines within the past 7 years prior to study participation. 2. High-resolution computed tomography (HRCT) scan at Screening, with ≥10% to <50% parenchymal fibrosis (reticulation) and <25% honeycombing. 3. FVCpp value >45% and <95% at Screening and Day 1 (prior to randomization). 4. Diffusing capacity of the lungs for carbon monoxide (DLCO) percent predicted ≥25% and ≤90%. 5. Not currently receiving treatment for IPF with an approved therapy for IPF (such as, pirfenidone or nintedanib) for any reason, including prior intolerance or lack of response to an approved IPF therapy, or choice to forego treatment with an approved IPF therapy after a full discussion with the Investigator regarding risks/benefits of such therapy. Key

Exclusion Criteria:

1. Previous exposure to pamrevlumab. 2. Evidence of significant obstructive lung disease, as evidenced by spirometry or HRCT. 3. Female participants who are pregnant or nursing. 4. Smoking within 3 months of Screening and/or unwilling to avoid smoking throughout the study. 5. Interstitial lung disease other than IPF. 6. Sustained improvement in the severity of IPF during the 12 months prior to screening. 7. Other types of respiratory diseases that, in the opinion of the Investigator, would impact the primary protocol endpoint or otherwise preclude participation in the study, including diseases of the airways, lung parenchyma, pleural space, mediastinum, diaphragm, or chest wall. 8. Certain medical conditions, that, in the opinion of the Investigator, would impact the primary protocol endpoint or otherwise preclude participation in the study (such as, myocardial infarction/stroke, severe chronic heart failure, pulmonary hypertension, or cancers). 9. Acute IPF exacerbation during Screening or Randomization including hospitalization due to acute IPF exacerbation within 4 weeks prior to or during screening. 10. Use of any investigational drugs or unapproved therapies, or participation in any clinical trial with an investigational new drug within 30 days prior to screening. Or use of approved IPF therapies (such as, pirfenidone or nintedanib) within 1 week prior to screening. 11. History of allergic or anaphylactic reaction to human, humanized, chimeric or murine monoclonal antibodies, or to any component of the excipient.

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT04419558
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 3
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

FibroGen
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

N/A
Principal Investigator Affiliation N/A
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Argentina, Brazil, China, Colombia, Czechia, Denmark, Dominican Republic, France, Georgia, Germany, Hungary, Ireland, Italy, Korea, Republic of, Lebanon, Mexico, Netherlands, Peru, Poland, Serbia, Spain, Switzerland, Ukraine, United Kingdom, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Idiopathic Pulmonary Fibrosis
Additional Details

The intent of this study is to evaluate the efficacy and safety of pamrevlumab as monotherapy in participants with IPF. Participants who are not being treated with approved IPF therapies (that is, nintedanib or pirfenidone) may be eligible for screening. Examples of reasons participants may not be treated with approved IPF therapies include but are not limited to:

  • - Intolerant or not responsive to approved IPF therapies.
  • - Ineligible to receive these therapies.
  • - Participant voluntarily declines to receive approved IPF therapies after being fully informed of the potential benefits/risks.
NOTE: No participant should discontinue an approved IPF therapy for the purpose of enrolling in this study. During the 48-week treatment phase of the study, co-administration of an approved IPF therapy (such as, pirfenidone or nintedanib) is acceptable if clinically indicated in the Investigator's opinion, after assessment of potential risks/benefits of such combination with blinded study treatment. Participants who complete the 48-week study will be eligible for an optional, open-label extension phase with continued access to pamrevlumab, regardless of their randomized assignment.

Arms & Interventions

Arms

Experimental: Pamrevlumab

Treatment phase: Pamrevlumab 30 mg/kg administered by IV infusion, every 3 weeks, for a total of up to 17 infusions over 48 weeks. Open-label extension phase: Pamrevlumab 30 mg/kg administered by intravenous infusion, every 3 weeks for up to 48 weeks

Experimental: Placebo

Pamrevlumab-matching placebo administered by IV infusion every 3 weeks for a total of up to 17 infusions over 48 weeks

Interventions

Drug: - Pamrevlumab

Sterile solution for injection

Drug: - Placebo

Sterile solution for injection

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

UAB Lung Health Center, Birmingham, Alabama

Status

Recruiting

Address

UAB Lung Health Center

Birmingham, Alabama, 35294

UC San Francisco, San Francisco, California

Status

Recruiting

Address

UC San Francisco

San Francisco, California, 94143

National Jewish Health, Denver, Colorado

Status

Recruiting

Address

National Jewish Health

Denver, Colorado, 80206

Yale University, New Haven, Connecticut

Status

Recruiting

Address

Yale University

New Haven, Connecticut, 06520

St. Francis Medical Center, Clearwater, Florida

Status

Recruiting

Address

St. Francis Medical Center

Clearwater, Florida, 33765

Kissimmee, Florida

Status

Recruiting

Address

Pulmonary Disease Specialists d/b/a PDS Research

Kissimmee, Florida, 34741

Tampa, Florida

Status

Recruiting

Address

TGH/USF Center for Advanced Lung Disease and Lung Transplant

Tampa, Florida, 33606

Emory University/The Emory Clinic, Atlanta, Georgia

Status

Recruiting

Address

Emory University/The Emory Clinic

Atlanta, Georgia, 30324

University of Iowa, Iowa City, Iowa

Status

Recruiting

Address

University of Iowa

Iowa City, Iowa, 52242

The University of Kansas Medical Center, Kansas City, Kansas

Status

Recruiting

Address

The University of Kansas Medical Center

Kansas City, Kansas, 66160

University of Maryland Medical Center, Baltimore, Maryland

Status

Recruiting

Address

University of Maryland Medical Center

Baltimore, Maryland, 21201

Boston, Massachusetts

Status

Recruiting

Address

The General Hospital Corporation d/b/a Massachusetts General Hospital

Boston, Massachusetts, 02114

Spectrum Health, Grand Rapids, Michigan

Status

Recruiting

Address

Spectrum Health

Grand Rapids, Michigan, 49504

University of Minnesota, Minneapolis, Minnesota

Status

Recruiting

Address

University of Minnesota

Minneapolis, Minnesota, 55455

Mayo Clinic, Rochester, Minnesota

Status

Recruiting

Address

Mayo Clinic

Rochester, Minnesota, 55905

Duke University Medical Center, Durham, North Carolina

Status

Recruiting

Address

Duke University Medical Center

Durham, North Carolina, 27710

PulmonIx, LLC, Greensboro, North Carolina

Status

Recruiting

Address

PulmonIx, LLC

Greensboro, North Carolina, 27403

Ohio State University, Columbus, Ohio

Status

Recruiting

Address

Ohio State University

Columbus, Ohio, 43221

Hershey, Pennsylvania

Status

Recruiting

Address

Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033

University of Pennsylvania, Philadelphia, Pennsylvania

Status

Recruiting

Address

University of Pennsylvania

Philadelphia, Pennsylvania, 19104

Low Country Lung and Critical Care, PA, Charleston, South Carolina

Status

Recruiting

Address

Low Country Lung and Critical Care, PA

Charleston, South Carolina, 29406

The University of Vermont, Burlington, Vermont

Status

Recruiting

Address

The University of Vermont

Burlington, Vermont, 05405

Madison, Wisconsin

Status

Recruiting

Address

University of Wisconsin Clinical Research

Madison, Wisconsin, 53706

International Sites

Ciudad Autonoma De Buenos Aires (CABA), Argentina

Status

Not yet recruiting

Address

Fundacion Respirar - Centro Médico Dra. De Salvo

Ciudad Autonoma De Buenos Aires (CABA), ,

Ciudad Autónoma de Buenos Aires, Argentina

Status

Not yet recruiting

Address

Centro de Investigacion Metabolica 'CINME'

Ciudad Autónoma de Buenos Aires, ,

INSARES, Ciudad de Mendoza, Argentina

Status

Not yet recruiting

Address

INSARES

Ciudad de Mendoza, ,

Florida, Argentina

Status

Not yet recruiting

Address

Centro Medico de Enfermedades Respiratorias

Florida, ,

Respira Salud Clinica Integral, Godoy Cruz, Argentina

Status

Not yet recruiting

Address

Respira Salud Clinica Integral

Godoy Cruz, ,

Instituto Ave Pulmo Fundacion Enfisema, Mar del Plata, Argentina

Status

Not yet recruiting

Address

Instituto Ave Pulmo Fundacion Enfisema

Mar del Plata, ,

Belo Horizonte, Minas Gerais, Brazil

Status

Recruiting

Address

Hospital das Clínicas da UFMG - Centro de Pesquisas Clínicas do Hospital das Clínicas da Universidade Federal de Minas Gerais - CPC HC/UFMG

Belo Horizonte, Minas Gerais, 30130-100

Porto Alegre, Rio Grande Do Sul, Brazil

Status

Recruiting

Address

Irmandade da Santa Casa de Misericórdia de Porto Alegre

Porto Alegre, Rio Grande Do Sul, 90020-090

Porto Alegre, Rio Grande Do Sul, Brazil

Status

Recruiting

Address

HSL-PUCRS Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul

Porto Alegre, Rio Grande Do Sul, 90610-000

Hospital Dia do Pulmão, Blumenau, Santa Catarina, Brazil

Status

Recruiting

Address

Hospital Dia do Pulmão

Blumenau, Santa Catarina, 89030-101

Botucatu, São Paulo, Brazil

Status

Recruiting

Address

Unidade de Pesquisa Clínica da Faculdade de Medicina de Botucatu - UPECLIN - UNESP

Botucatu, São Paulo, 18618-686

Sao Bernardo do Campo, São Paulo, Brazil

Status

Recruiting

Address

CEMEC - Centro Multidisciplinar de Estudos Clínicos LTDA EPP

Sao Bernardo do Campo, São Paulo, 09715-090

CPQuali Pesquisa Clínica Ltda., São Paulo, Brazil

Status

Recruiting

Address

CPQuali Pesquisa Clínica Ltda.

São Paulo, , 01228-000

Hospital Alemao Oswaldo Cruz, São Paulo, Brazil

Status

Recruiting

Address

Hospital Alemao Oswaldo Cruz

São Paulo, , 01323-001

São Paulo, Brazil

Status

Recruiting

Address

INCOR - Instituto do Coração Centro de Pesquisa Prof. Dr. Fulvio Pileggi Hospital das Clínicas da Faculdade de Medicina da USP - HCFMUSP

São Paulo, , 05403-000

Beijing, China

Status

Recruiting

Address

BeiJing Chao-Yang Hospital,Capital Medical University

Beijing, ,

Beijing, China

Status

Recruiting

Address

Beijing Frindship hosiptal capital Medical University

Beijing, ,

China Japan Friendship hospital, Beijing, China

Status

Recruiting

Address

China Japan Friendship hospital

Beijing, ,

Peking Union Medical College Hospital, Beijing, China

Status

Recruiting

Address

Peking Union Medical College Hospital

Beijing, ,

Sichuan People's Hospital, Chengdu, China

Status

Recruiting

Address

Sichuan People's Hospital

Chengdu, ,

Guangdong Provincial People's Hospital, Guangzhou, China

Status

Recruiting

Address

Guangdong Provincial People's Hospital

Guangzhou, ,

Hangzhou, China

Status

Not yet recruiting

Address

Affiliated Hangzhou First People's Hospital,

Hangzhou, ,

Hangzhou, China

Status

Recruiting

Address

The Second Affiliated Hospital of Zhejiang University School of Medicine

Hangzhou, ,

Hunan, China

Status

Not yet recruiting

Address

The Second Xiangya Hospital of Central South University

Hunan, ,

The First Hospital of Lanzhou University, Lanzhou, China

Status

Not yet recruiting

Address

The First Hospital of Lanzhou University

Lanzhou, ,

Shandong Provincal Qianfoshan Hospital, Shandong, China

Status

Not yet recruiting

Address

Shandong Provincal Qianfoshan Hospital

Shandong, ,

Shanghai, China

Status

Recruiting

Address

Ruijin Hospital, Shanghai Jiaotong University School of Medicine

Shanghai, ,

Shanghai Oriental Hospital, Shanghai, China

Status

Recruiting

Address

Shanghai Oriental Hospital

Shanghai, ,

Shanghai Oriental Hospital, Shanghai, China

Status

Recruiting

Address

Shanghai Oriental Hospital

Shanghai, ,

Shenyang, China

Status

Recruiting

Address

The First Hospital of China Medical University

Shenyang, ,

Shenzhen People's Hospital, Shenzhen, China

Status

Not yet recruiting

Address

Shenzhen People's Hospital

Shenzhen, ,

Tianjing, China

Status

Recruiting

Address

General Hospital of Tianjin Medical University

Tianjing, ,

Wuhan, China

Status

Recruiting

Address

Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology

Wuhan, ,

Wuhan, China

Status

Recruiting

Address

Union Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, ,

Xian, China

Status

Recruiting

Address

The Second Affiliated Hospital of Xi'an Jiaotong University

Xian, ,

Yinchuan, China

Status

Recruiting

Address

General Hospital of Ningxia Medical University

Yinchuan, ,

Fundación Santa Fe de Bogotá, Bogota, Colombia

Status

Recruiting

Address

Fundación Santa Fe de Bogotá

Bogota, , 110121

Fundación Neumológica Colombiana, Bogota, Colombia

Status

Recruiting

Address

Fundación Neumológica Colombiana

Bogota, , 110131

Caja de Compensación Familiar CAFAM, Bogota, Colombia

Status

Not yet recruiting

Address

Caja de Compensación Familiar CAFAM

Bogota, , 111211

Healthy Medical Center S.A.S, Zipaquirá, Colombia

Status

Recruiting

Address

Healthy Medical Center S.A.S

Zipaquirá, , 250252

Fakultní nemocnice Brno, Brno, Czechia

Status

Recruiting

Address

Fakultní nemocnice Brno

Brno, , 625 00

Nemocnice Jihlava, Jihlava, Czechia

Status

Recruiting

Address

Nemocnice Jihlava

Jihlava, , 586 33

Prague, Czechia

Status

Recruiting

Address

Nemocnice Na Bulovce, Klinika pneumologie

Prague, , 18081

Aarhus Universitets Hospital, Aarhus, Denmark

Status

Recruiting

Address

Aarhus Universitets Hospital

Aarhus, , DK-8200

Odense University Hospital, Odense, Denmark

Status

Recruiting

Address

Odense University Hospital

Odense, , 5000

Centro de Obstetricia y Ginecologia, Santo Domingo, Dominican Republic

Status

Completed

Address

Centro de Obstetricia y Ginecologia

Santo Domingo, , 10205

Centro Medico Dominicano, Santo Domingo, Dominican Republic

Status

Completed

Address

Centro Medico Dominicano

Santo Domingo, , 456

University Hospital Avicenne, Bobigny, France

Status

Recruiting

Address

University Hospital Avicenne

Bobigny, , 93000

Bron, France

Status

Recruiting

Address

Hôpital Cardio-Vasculaire et Pneumologique Louis Pradel

Bron, , 69677

CHU de Caen, Caen, France

Status

Recruiting

Address

CHU de Caen

Caen, , 14033

Dijon, France

Status

Recruiting

Address

Centre Memoire Ressources Recherche, Hopital F. MITTERRAND

Dijon, , 21079

Montpellier, France

Status

Recruiting

Address

C.H.R.U. de Montpellier - Hôpital Lapeyronie

Montpellier, , 34295

CHU de Nice Hôpital Pasteur, Nice, France

Status

Recruiting

Address

CHU de Nice Hôpital Pasteur

Nice, , 06000

Hôpital Bichat - Claude Bernard, Paris, France

Status

Recruiting

Address

Hôpital Bichat - Claude Bernard

Paris, , 75018

CHU de Reims Hopital Maison Blanche, Reims, France

Status

Recruiting

Address

CHU de Reims Hopital Maison Blanche

Reims, , 51092

CHU de Rennes Hôpital Pontchaillou, Rennes, France

Status

Recruiting

Address

CHU de Rennes Hôpital Pontchaillou

Rennes, , 35033

Tours, France

Status

Recruiting

Address

Service de Néphrologie, Hôpital Bretonneau, CHRU de Tours

Tours, , 37044

Tbilisi, Georgia

Status

Recruiting

Address

Research Institute Of Clinical Medicine Todua Clinic

Tbilisi, , 0112

Clinic Diacor, Tbilisi, Georgia

Status

Recruiting

Address

Clinic Diacor

Tbilisi, , 0159

Essen, Germany

Status

Recruiting

Address

Ruhrlandklinik-Universitaetsmedizin Essen

Essen, , 45239

Klinik Schillerhoehe, Gerlingen, Germany

Status

Recruiting

Address

Klinik Schillerhoehe

Gerlingen, , 70839

Site Contact

Research Center

zephyrus@fibrogen.com

(415) 978-1427

Gießen, Germany

Status

Recruiting

Address

Agaplesion Evangelisches Krankenhaus Mittelhessen

Gießen, , 035398

Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

Status

Recruiting

Address

Universitätsklinikum Hamburg-Eppendorf

Hamburg, , 20246

University of Munich, Munich, Germany

Status

Recruiting

Address

University of Munich

Munich, , 81377

RoMed Klinikum Rosenheim, Rosenheim, Germany

Status

Recruiting

Address

RoMed Klinikum Rosenheim

Rosenheim, , 83022

Solingen, Germany

Status

Recruiting

Address

Institut fur Pneumologie an der Universitat zu Koln

Solingen, , 83022

Budapest, Hungary

Status

Recruiting

Address

Semmelweis University Clinic of Pulmonology

Budapest, , 1083

Budapest, Hungary

Status

Recruiting

Address

Orszagos Koranyi Tbc es Pulmonologiai Intezet, IV. Tudobelosztaly

Budapest, , 1121

Fejer Megyei Szent Gyorgy kh, Szekesfehervar, Hungary

Status

Recruiting

Address

Fejer Megyei Szent Gyorgy kh

Szekesfehervar, , 8000

Pulmonology Hospital, Törökbálint, Hungary

Status

Recruiting

Address

Pulmonology Hospital

Törökbálint, , 2045

Royal College of Surgeons in Ireland, Dublin, Ireland

Status

Recruiting

Address

Royal College of Surgeons in Ireland

Dublin, , D09YD60

Gaspare Rodiloco Hospital, Catania, Italy

Status

Recruiting

Address

Gaspare Rodiloco Hospital

Catania, , 95123

Forli, Italy

Status

Recruiting

Address

Ospedale G.B.Morgagni L.Pierantoni - Azienda Unita Sanitaria Locale (AUSL) di Forli

Forli, , 47121

Ospedale San Giuseppe, Milan, Italy

Status

Recruiting

Address

Ospedale San Giuseppe

Milan, , 20123

AOU Policlinico di Modena, Modena, Italy

Status

Recruiting

Address

AOU Policlinico di Modena

Modena, , 41124

Monaldi Hospital, Naples, Italy

Status

Recruiting

Address

Monaldi Hospital

Naples, , 80131

Padova, Italy

Status

Recruiting

Address

Azienda Ospedaliera Universitaria di Padova

Padova, , 35128

IRCCS Fondazione San Matteo di Pavia, Pavia, Italy

Status

Recruiting

Address

IRCCS Fondazione San Matteo di Pavia

Pavia, , 27100

Agostina Gemelli University Polyclinic, Rome, Italy

Status

Recruiting

Address

Agostina Gemelli University Polyclinic

Rome, , 00168

Siena, Italy

Status

Recruiting

Address

Azienda Ospedaliera Universitaria Senese, Policlinico "Le Scotte"

Siena, , 53100

Torino, Italy

Status

Recruiting

Address

Azienda Ospedaliera Citta' della Salute e delle Scienza di Torino

Torino, , 0126

Torrette, Italy

Status

Recruiting

Address

Azienda Ospedaliero-Universitaria "Ospedali Riuniti di Ancona"

Torrette, , 60126

Myongji Hospital, Goyang-si, Gyeonggi-do, Korea, Republic of

Status

Recruiting

Address

Myongji Hospital

Goyang-si, Gyeonggi-do, 10475

Bucheon-si, Korea, Republic of

Status

Recruiting

Address

Soonchunhyang University Hospital Bucheon

Bucheon-si, , 14584

Bucheon, Korea, Republic of

Status

Recruiting

Address

The Catholic University of Korea Bucheon St. Mary's Hospital

Bucheon, , 14647

Inje University Haeundae Paik Hospital, Busan, Korea, Republic of

Status

Recruiting

Address

Inje University Haeundae Paik Hospital

Busan, , 48108

Goyang, Korea, Republic of

Status

Recruiting

Address

Inje University Hospital Iisan Paik Hospital

Goyang, , 10380

Chonnam National University Hospital, Gwangju, Korea, Republic of

Status

Recruiting

Address

Chonnam National University Hospital

Gwangju, , 61469

Gachon University Gil Medical Centre, Incheon, Korea, Republic of

Status

Recruiting

Address

Gachon University Gil Medical Centre

Incheon, , 21565

Seongnam, Korea, Republic of

Status

Recruiting

Address

Seoul National University Bundang Hospital

Seongnam, , 13620

Seoul National University Hospital, Seoul, Korea, Republic of

Status

Recruiting

Address

Seoul National University Hospital

Seoul, , 03080

Kyunghee University Medical Center, Seoul, Korea, Republic of

Status

Recruiting

Address

Kyunghee University Medical Center

Seoul, , 17104

Severance hospital, Seoul, Korea, Republic of

Status

Recruiting

Address

Severance hospital

Seoul, , 3722

Soonchunhyang University Hospital Seoul, Seoul, Korea, Republic of

Status

Recruiting

Address

Soonchunhyang University Hospital Seoul

Seoul, , 4401

Asan Medical Center, Seoul, Korea, Republic of

Status

Recruiting

Address

Asan Medical Center

Seoul, , 5505

Seoul, Korea, Republic of

Status

Not yet recruiting

Address

The Catholic University of Korea, Seoul ST. Mary's Hospital

Seoul, , 6591

Seoul, Korea, Republic of

Status

Recruiting

Address

The Catholic University of Korea, Yeouido ST. Mary's Hospital

Seoul, , 7345

Ulsan University Hospital, Ulsan, Korea, Republic of

Status

Recruiting

Address

Ulsan University Hospital

Ulsan, , 44033

Beirut, Lebanon

Status

Recruiting

Address

American University of beirut medical center

Beirut, ,

Hotel Dieu De France, Beirut, Lebanon

Status

Recruiting

Address

Hotel Dieu De France

Beirut, ,

Bir Hassan, Lebanon

Status

Recruiting

Address

Rafik Hariri University Hospital (Clinical Research Unit)

Bir Hassan, ,

Mexico, Mexico

Status

Recruiting

Address

Instituto Nacional de Enfermedades Respiratorias INER

Mexico, , 14080

Mexico, Mexico

Status

Recruiting

Address

Unidad Medica para la Salud Integral (UMSI)

Mexico, , 66465

Medical Care and Research S.A. de C.V., Mexico, Mexico

Status

Recruiting

Address

Medical Care and Research S.A. de C.V.

Mexico, , 97070

Mexico, Mexico

Status

Recruiting

Address

St. Lucas Clinical Research Center SA de CV

Mexico, , CP97217

Monterrey, Mexico

Status

Recruiting

Address

Centro Regional para el estudio del Adulto Mayor, Servicio de Geriatria, Hospital Universitario Dr Jose Eleuterio Gonzalez

Monterrey, , 64460

Oaxaca, Mexico

Status

Recruiting

Address

Oaxaca Site Management Organization S.C. (OSMO)

Oaxaca, , 68000

Dept. of Pulmonary Diseases, Amsterdam, Netherlands

Status

Recruiting

Address

Dept. of Pulmonary Diseases

Amsterdam, , 30.033

Catharina Hospital, Eindhoven, Netherlands

Status

Recruiting

Address

Catharina Hospital

Eindhoven, , 5623 EJ

Heerlen, Netherlands

Status

Recruiting

Address

Longarts - Opleider Longziekten Zuyderland MC

Heerlen, , 6419

St. Antonius Ziekenhuis BV, Nieuwegein, Netherlands

Status

Recruiting

Address

St. Antonius Ziekenhuis BV

Nieuwegein, , 3435

Canisius-Wilhelmina Ziekenhuis, Nieuwegein, Netherlands

Status

Recruiting

Address

Canisius-Wilhelmina Ziekenhuis

Nieuwegein, , 6533

Clinica Internacional, Lima, Peru

Status

Recruiting

Address

Clinica Internacional

Lima, , 15001

Clinica San Pablo, Lima, Peru

Status

Recruiting

Address

Clinica San Pablo

Lima, , 150140

Clinica Providencia, Lima, Peru

Status

Recruiting

Address

Clinica Providencia

Lima, , 15088

Lima, Peru

Status

Recruiting

Address

Hospital Nacional Cayetano Heredia / Servicio de Inmunología y Reumatología

Lima, , 15102

Centro de Investigacion Ricardo Palma, San Isidro, Peru

Status

Recruiting

Address

Centro de Investigacion Ricardo Palma

San Isidro, , 150131

Clinica La luz, Santa Beatriz, Peru

Status

Recruiting

Address

Clinica La luz

Santa Beatriz, , 15046

Bedzin, Poland

Status

Recruiting

Address

Centrum Dentystyczno-Lekarskie Promedica Joanna Markiewicz

Bedzin, , 42-500

Centrum Medycyny Oddechowej Mroz SJ, Bialystok, Poland

Status

Recruiting

Address

Centrum Medycyny Oddechowej Mroz SJ

Bialystok, , 15-044

Katowice, Poland

Status

Recruiting

Address

Gornoslaskie Centrum Medyczne im. prof. Leszka Gieca Slaskiego Uniwersytetu Medycznego w Katowicach

Katowice, , 40-635

University Hospital No1, Lodz, Poland

Status

Recruiting

Address

University Hospital No1

Lodz, , 90-153

Instytut Gruzlicy i Chorob Pluc, Warsaw, Poland

Status

Recruiting

Address

Instytut Gruzlicy i Chorob Pluc

Warsaw, , 01-138

Belgrade, Serbia

Status

Recruiting

Address

Municipal Institute for Lung Diseases and Tuberculosis

Belgrade, , 11000

University Clinical Center of Serbia, Belgrade, Serbia

Status

Recruiting

Address

University Clinical Center of Serbia

Belgrade, , 11000

University Clinical Center of Nis, Nis, Serbia

Status

Recruiting

Address

University Clinical Center of Nis

Nis, , 18000

Sremska Kamenica, Serbia

Status

Recruiting

Address

Institute for Pulmonary Diseases of Vojvodina

Sremska Kamenica, , 21204

Hospital Universitario de Bellvitge, Barcelona, Spain

Status

Recruiting

Address

Hospital Universitario de Bellvitge

Barcelona, , 08907

Hospital Clinic de Barcelona, Barcelona, Spain

Status

Recruiting

Address

Hospital Clinic de Barcelona

Barcelona, , 8036

Hospital Universitaio de La Princesa, Madrid, Spain

Status

Recruiting

Address

Hospital Universitaio de La Princesa

Madrid, , 28006

Madrid, Spain

Status

Recruiting

Address

Hospital General Universitario Gregorio Maranon

Madrid, , 28007

Madrid, Spain

Status

Recruiting

Address

Hospital Clinico San Carlos-Madrid C/Martin Lagos s/n

Madrid, , 28040

Madrid, Spain

Status

Recruiting

Address

Hospital Universitario Quironsalud Madrid

Madrid, , 28223

Santander, Spain

Status

Recruiting

Address

Hospital Universitario Marques de Valdecilla

Santander, , 39008

Sevilla, Spain

Status

Recruiting

Address

Hospital Universitario Nuestra Senora de Valme

Sevilla, , 41014

Universitätsklinik für Pneumologie, Bern, Switzerland

Status

Recruiting

Address

Universitätsklinik für Pneumologie

Bern, , 3010

Dnipro, Ukraine

Status

Recruiting

Address

Communal non-profit enterprise "City clinical hospital #16" of Dnipro Сit Сouncil

Dnipro, , 49069

Ivano-Frankivsk, Ukraine

Status

Recruiting

Address

Ivano-Frankivsk Regional Phthisiology-Pulmonology Center of Ivano-Frankivsk regional council

Ivano-Frankivsk, , 76018

Kyiv, Ukraine

Status

Recruiting

Address

National Institute of Phthisiology and Pulmonology named after F. G. Yanovskyi NAMS of Ukraine, Clinical and Functional Department

Kyiv, , 03680

Kyiv, Ukraine

Status

Recruiting

Address

National Institute of Phthisiology and Pulmonology named after F. G. Yanovskyi NAMS of Ukraine, Clinical and Functional Department

Kyiv, , 03680

Medway NHS Foundation Trust, Gillingham, Kent, United Kingdom

Status

Recruiting

Address

Medway NHS Foundation Trust

Gillingham, Kent, ME7 5NY

Birmingham, United Kingdom

Status

Recruiting

Address

Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust

Birmingham, , B15 2TH

Cambridge, United Kingdom

Status

Recruiting

Address

Papworth Hospital NHS Foundation Trust, Advanced Heart Failure Unit

Cambridge, , CB2 0AY

Harlow, United Kingdom

Status

Recruiting

Address

The Princess Alexandra Hospital NHS Trust

Harlow, , CM20 1QX

Royal Brompton Hospital, London, United Kingdom

Status

Recruiting

Address

Royal Brompton Hospital

London, , SW3 6NP

University College London, London, United Kingdom

Status

Recruiting

Address

University College London

London, , WC1E 6JF

Manchester, United Kingdom

Status

Recruiting

Address

Manchester University NHS Foundation Trust

Manchester, , M23 9LT

Southampton General Hospital, Southampton, United Kingdom

Status

Recruiting

Address

Southampton General Hospital

Southampton, , SO16 6YD